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Article

Estimation of genotype relative risks from pedigree data by retrospective likelihoods.

Genetic epidemiology - 1 May 2010

Schaid Daniel J, McDonnell Shannon K, Riska Shaun M, Carlson Erin E, Thibodeau Stephen N

Abstract excerpt

Pedigrees collected for linkage studies are a valuable resource that could be used to estimate genetic relative risks (RRs) for genetic variants recently discovered in case-control genome wide association studies. To estimate RRs from highly ascertained pedigrees, a pedigree "retrospective likelihood" can be used, which adjusts for ascertainment by conditioning on the phenotypes of pedigree members. We explore a...

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Identifiers

PMID: 20039378
DOI: 10.1002/gepi.20460
PMCID: PMC2860197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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