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Article

Hierarchical modeling for estimating relative risks of rare genetic variants: properties of the pseudo-likelihood method.

Biometrics - 1 Jun 2011

Capanu Marinela, Begg Colin B

Abstract excerpt

Many major genes have been identified that strongly influence the risk of cancer. However, there are typically many different mutations that can occur in the gene, each of which may or may not confer increased risk. It is critical to identify which specific mutations are harmful, and which ones are harmless, so that individuals who learn from genetic testing that they have a mutation can be appropriately...

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Identifiers

PMID: 20707869
DOI: 10.1111/j.1541-0420.2010.01469.x
PMCID: PMC3015025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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