HFE p.H63D polymorphism does not influence ALS phenotype and survival.

doi:10.1016/j.neurobiolaging.2015.06.016

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Article

HFE p.H63D polymorphism does not influence ALS phenotype and survival.

Neurobiology of aging - 1 Oct 2015

Chiò Adriano, Mora Gabriele, Sabatelli Mario, Caponnetto Claudia, Lunetta Christian, Traynor Bryan J, Johnson Janel O, Nalls Mike A, Calvo Andrea, Moglia Cristina, Borghero Giuseppe, Monsurrò Maria Rosaria, La Bella Vincenzo, Volanti Paolo, Simone Isabella, Salvi Fabrizio, Logullo Francesco O, Nilo Riva, Giannini Fabio, Mandrioli Jessica, Tanel Raffaella, Murru Maria Rita, Mandich Paola, Zollino Marcella, Conforti Francesca L, Penco Silvana, Brunetti Maura, Barberis Marco, Restagno Gabriella

Abstract excerpt

It has been recently reported that the p.His63Asp polymorphism of the HFE gene accelerates disease progression both in the SOD1 transgenic mouse and in amyotrophic lateral sclerosis (ALS) patients. We have evaluated the effect of HFE p.His63Asp polymorphism on the phenotype in 1351 Italian ALS patients (232 of Sardinian ancestry). Patients were genotyped for the HFE p.His63Asp polymorphism (CC, GC, and GG). All...

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Identifiers

PMID: 26174855
DOI: 10.1016/j.neurobiolaging.2015.06.016
PMCID: PMC5183653

Genes

HFE
SOD1
FUS
TARDBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HFE p.H63D polymorphism does not influence ALS phenotype and survival.PMID 26174855Read ↗

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