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Article

Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Feb 2014

Li M, Wang L, Wang W, Qi X L, Tang Z Y

Abstract excerpt

Iron homeostasis dysregulation has been regarded as an important mechanism in neurodegenerative diseases. The H63D and C282Y polymorphisms in the HFE gene may be involved in the development of sporadic amyotrophic lateral sclerosis (ALS) through the disruption of iron homeostasis. However, studies investigating the relationship between ALS and these two polymorphisms have yielded contradictory outcomes. We...

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Identifiers

PMID: 24604426
DOI: 10.1590/1414-431X20133296
PMCID: PMC3982942

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies.PMID 24604426Read ↗

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H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.Semantic proximity Read ↗

H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population.Semantic proximity Read ↗

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