H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.

doi:10.1016/j.neurobiolaging.2012.07.020

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Article

H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.

Neurobiology of aging - 1 May 2013

van Rheenen Wouter, Diekstra Frank P, van Doormaal Perry T C, Seelen Meinie, Kenna Kevin, McLaughlin Russell, Shatunov Aleksey, Czell David, van Es Michael A, van Vught Paul W J, van Damme Philip, Smith Bradley N, Waibel Stefan, Schelhaas H Jurgen, van der Kooi Anneke J, de Visser Marianne, Weber Markus, Robberecht Wim, Hardiman Orla, Shaw Pamela J, Shaw Christopher E, Morrison Karen E, Al-Chalabi Ammar, Andersen Peter M, Ludolph Albert C, Veldink Jan H, van den Berg Leonard H

Abstract excerpt

The H63D polymorphism in HFE has frequently been associated with susceptibility to amyotrophic lateral sclerosis (ALS). Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS. Furthermore, novel therapeutic strategies are being developed targeti...

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PMID: 23063643
DOI: 10.1016/j.neurobiolaging.2012.07.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23063643-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.PMID 23063643Read ↗

Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies.Semantic proximity Read ↗

The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population.Semantic proximity Read ↗

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HFE mutations are not strongly associated with sporadic ALS.Semantic proximity Read ↗

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H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients.Semantic proximity Read ↗

H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population.Semantic proximity Read ↗

H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China.Semantic proximity Read ↗

Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS.Semantic proximity Read ↗

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