Article
The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population.
Archives of neurology - 1 Jan 2007
Sutedja Nadia A, Sinke Richard J, Van Vught Paul W J, Van der Linden Michiel W, Wokke John H J, Van Duijn Cornelia M, Njajou Omer T, Van der Schouw Yvonne T, Veldink Jan H, Van den Berg Leonard H
Abstract excerpt
BACKGROUND: Mutations in HFE, a gene defect that can disrupt iron metabolism, have been implicated in increasing the risk of developing amyotrophic lateral sclerosis (ALS). OBJECTIVE: To further establish the association between ALS and HFE mutations by investigating whether HFE mutations are associated with an increased risk of developing ALS in a population in The Netherlands and by pooling our results with...
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