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Article

H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients.

Muscle & nerve - 1 Aug 2013

Su Xiaowei W, Lee Sang Y, Mitchell Ryan M, Stephens Helen E, Simmons Zachary, Connor James R

Abstract excerpt

INTRODUCTION: H63D HFE polymorphisms increase the risk of neurodegenerative disorders and, specifically, may increase amyotrophic lateral sclerosis (ALS) risk. Investigating the physiological alterations induced by H63D polymorphisms in ALS patients may elucidate mechanisms by which this genotype alters disease. METHODS: Clinical measures and muscle biopsies were available from patients previously diagnosed with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23813494
DOI: 10.1002/mus.23740

Genes

HFE
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients.PMID 23813494Read ↗

The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population.Semantic proximity Read ↗

H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies.Semantic proximity Read ↗

Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis.Semantic proximity Read ↗

H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China.Semantic proximity Read ↗

HFE H63D polymorphism is increased in patients with amyotrophic lateral sclerosis of Italian originSemantic proximity Read ↗

Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis.Semantic proximity Read ↗

H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population.Semantic proximity Read ↗

Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences.Semantic proximity Read ↗

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.Semantic proximity Read ↗

HFE p.H63D polymorphism does not influence ALS phenotype and survival.Semantic proximity Read ↗

Association between divalent metal transport 1 encoding gene (SLC11A2) and disease duration in amyotrophic lateral sclerosis.Semantic proximity Read ↗

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