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Article

HFE H63D polymorphism is increased in patients with amyotrophic lateral sclerosis of Italian origin

20 Oct 2006

Abstract excerpt

A role for metal-mediated oxidative stress in the pathogenesis of amyotrophic lateral sclerosis (ALS) was proposed in 1994 in the first studies of familial ALS mutant superoxide dismutase 1, and interference with iron homoeostasis is now postulated.1 The HFE gene on chromosome 6 is a mean corpuscular haemoglobin class I-like molecule related to iron regulation. Mutations in the coding region cause hereditary...

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PMID: 17308297
DOI: 10.1136/jnnp.2006.092338

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HFE H63D polymorphism is increased in patients with amyotrophic lateral sclerosis of Italian originPMID 17308297Read ↗

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