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Article

Common and rare variants in HFE are not associated with Parkinson's disease in Europeans.

Neurobiology of aging - 1 Nov 2021

Saini Prabhjyot, Bandres-Ciga Sara, Alcantud Jose Luis, Ruz Clara, Postuma Ronald B, Gan-Or Ziv

Abstract excerpt

A recent study suggested that the p.H63D variant in HFE, a gene involved in iron homeostasis, may modify α-synuclein pathology, the pathological hallmark of Parkinson's disease (PD). If indeed this gene and specific variant are involved in PD, we expect to find differential distribution of HFE variants when comparing PD patients and controls. We analyzed genome-wide association study (GWAS) data from 14,671 PD...

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Identifiers

PMID: 34215448
DOI: 10.1016/j.neurobiolaging.2021.05.019
PMCID: PMC8595489

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