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Article

Mechanics in human fibroblasts and progeria: Lamin A mutation E145K results in stiffening of nuclei.

Journal of molecular recognition : JMR - 1 Feb 2017

Apte Ketaki, Stick Reimer, Radmacher Manfred

Abstract excerpt

The lamina is a filamentous meshwork beneath the inner nuclear membrane that confers mechanical stability to nuclei. The E145K mutation in lamin A causes Hutchinson-Gilford progeria syndrome (HGPS). It affects lamin filament assembly and induces profound changes in the nuclear architecture. Expression of wild-type and E145K lamin A in Xenopus oocytes followed by atomic force microscopy (AFM) probing of isolated...

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PMID: 27677907
DOI: 10.1002/jmr.2580

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AFM

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