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Article

ESCRT-III controls nuclear envelope deformation induced by progerin.

Scientific reports - 2 Nov 2020

Arii Jun, Maeda Fumio, Maruzuru Yuhei, Koyanagi Naoto, Kato Akihisa, Mori Yasuko, Kawaguchi Yasushi

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder, caused by mutation in the gene encoding lamin A/C, which produces a truncated protein called progerin. In cells from HGPS patients, progerin accumulates at the nuclear membrane (NM), where it causes NM deformations. In this study, we investigated whether progerin-induced NM deformation involved ESCRT-III, a protein complex that remodels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33139753
DOI: 10.1038/s41598-020-75852-6
PMCID: PMC7606583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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