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Article

Targeted Nasal Vaccination Provides Antibody-Independent Protection Against Staphylococcus aureus

22 Nov 2013

Abstract excerpt

Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles...

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Share to Antimicrobial Peptides and Activities
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PMID: 24273045
DOI: 10.1093/infdis/jit636

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