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<i>Staphylococcus aureus</i> Protein A Disrupts Immunity Mediated by Long-Lived Plasma Cells

29 Dec 2016

Abstract excerpt

Infection with Staphylococcus aureus does not induce long-lived protective immunity for reasons that are not completely understood. Human and murine vaccine studies support a role for Abs in protecting against recurring infections, but S. aureus modulates the B cell response through expression of staphylococcus protein A (SpA), a surface protein that drives polyclonal B cell expansion and induces cell death in...

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PMID: 28031339
DOI: 10.4049/jimmunol.1600093

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