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Article

Ageing adversely affects the migration and function of marginal zone B cells.

Immunology - 1 Jul 2017

Turner Vivian M, Mabbott Neil A

Abstract excerpt

Marginal zone (MZ) B cells are positioned within the spleen to capture blood-borne antigen and immune complexes and deliver them to follicular dendritic cells in the B-cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, were impaired. The ability of aged MZ B cells to migrate towards the MZ chemoattractant...

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Identifiers

PMID: 28369800
DOI: 10.1111/imm.12737
PMCID: PMC5461100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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