Article
Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility.
BioMed research international - 1 Jan 2015
Liu Yehua, Qiu Fuman, Yang Lei, Yang Rongrong, Yang Xiaorong, Huang Dongsheng, Fang Wenxiang, Zhang Lisha, Jiang Qingping, Zhang Lan, Zhou Yifeng, Lu Jiachun
Abstract excerpt
Nasopharyngeal carcinoma (NPC) is a multifactoral and polygenic disease with high prevalence in Southeast Asia and Southern China. Environmental factors and genetic susceptibility play important roles in NPC pathogenesis. In the present study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) in nuclear factor-kappa B (NFκB) and its inhibitor (IκBα) conferred consistent risks for NPC. Four...
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