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Functional polymorphisms in NFκB1/IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.

Human genetics - 1 Apr 2013

Huang Dongsheng, Yang Lei, Liu Yehua, Zhou Yumin, Guo Yuan, Pan Mingan, Wang Yunnan, Tan Yigang, Zhong Haibo, Hu Min, Lu Wenju, Ji Weidong, Wang Jian, Ran Pixin, Zhong Nanshan, Zhou Yifeng, Lu Jiachun

Abstract excerpt

Lung inflammation is the major pathogenetic feature for both chronic obstructive pulmonary disease (COPD) and lung cancer. The nuclear factor-kappa B (NFκB) and its inhibitor (IκB) play crucial roles in inflammatory. Here, we tested the hypothesis that single nucleotide polymorphisms (SNPs) in NFκB/IκB confer consistent risks for COPD and lung cancer. Four putative functional SNPs (NFκB1: -94del>insATTG; NFκB2:...

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PMID: 23322360
DOI: 10.1007/s00439-013-1264-9

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