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Article

A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population-based and in vitro study.

Cancer medicine - 1 May 2018

Chen Fa, Liu Fengqiong, Yan Lingjun, Lin Lisong, Qiu Yu, Wang Jing, Wu Junfeng, Bao Xiaodan, Hu Zhijian, Cai Lin, He Baochang

Abstract excerpt

Genetic variations of NF-κB and its inhibitor IκB genes and their biological mechanism in oral cancer were not well recognized. The purpose of this study was to evaluate the associations of polymorphisms in NFKB1 and NFKBIA with oral cancer susceptibility, and further explore their potential mechanism in vitro. First, the polymorphisms of NFKB1 and NFKBIA were genotyped through iPLEX Sequenom MassARRAY platform...

Topics

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Biomarkers, Tumor
Carcinoma, Squamous Cell
Cell Line, Tumor
Electrophoretic Mobility Shift Assay
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

NF-kappa B p50 Subunit

NF-KappaB Inhibitor alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 29635862
DOI: 10.1002/cam4.1453
PMCID: PMC5943439

Genes

NFKB1
NFKBIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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