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Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation.

Cell genomics - 14 Feb 2024

Xu Miao, Feng Ruimei, Liu Zhonghua, Zhou Xiang, Chen Yanhong, Cao Yulu, Valeri Linda, Li Zilin, Liu Zhiwei, Cao Su-Mei, Liu Qing, Xie Shang-Hang, Chang Ellen T, Jia Wei-Hua, Shen Jincheng, Yao Youyuan, Cai Yong-Lin, Zheng Yuming, Zhang Zhe, Huang Guangwu, Ernberg Ingemar, Tang Minzhong, Ye Weimin, Adami Hans-Olov, Zeng Yi-Xin, Lin Xihong

Abstract excerpt

Epstein-Barr virus (EBV) and human leukocyte antigen (HLA) polymorphisms are well-known risk factors for nasopharyngeal carcinoma (NPC). However, the combined effects between HLA and EBV on the risk of NPC are unknown. We applied a causal inference framework to disentangle interaction and mediation effects between two host HLA SNPs, rs2860580 and rs2894207, and EBV variant 163364 with a population-based...

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Share to Case-Control Studies
Share to Epstein-Barr Virus Infections
Share to Herpesvirus 4, Human
Share to Nasopharyngeal Carcinoma
Share to Nasopharyngeal Neoplasms
Share to Polymorphism, Single Nucleotide
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Identifiers

PMID: 38359790
DOI: 10.1016/j.xgen.2023.100474
PMCID: PMC10879020

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