Article
Association of transforming growth factor-beta1 gene polymorphisms with genetic susceptibility to nasopharyngeal carcinoma.
Clinica chimica acta; international journal of clinical chemistry - 1 May 2007
Wei Ye-Sheng, Zhu Yin-Hua, Du Bing, Yang Zhi-Hui, Liang Wei-Bo, Lv Mei-Li, Kuang Xiang-Hong, Tai Shu-Hong, Zhao Yu, Zhang Lin
Abstract excerpt
BACKGROUND: Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine, it promotes tumor growth and metastasis in later stages of phase of cancer development. Variations in the DNA sequence in the TGF-beta1 gene may lead to altered TGF-beta1 production and/or activity, and so this can...
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