Article
Contribution of Rare and Common Genetic Variants to Plasma Lipid Levels and Carotid Stiffness and Geometry: A Substudy of the Paris Prospective Study 3.
Circulation. Cardiovascular genetics - 1 Aug 2015
Proust Carole, Empana Jean-Philippe, Boutouyrie Pierre, Alivon Maureen, Challande Pascal, Danchin Nicolas, Escriou Guillaume, Esslinger Ulrike, Laurent Stéphane, Li Zhenlin, Pannier Bruno, Regnault Veronique, Thomas Frederique, Jouven Xavier, Cambien François, Lacolley Patrick
Abstract excerpt
BACKGROUND: We assess the contribution of common and rare putatively functional genetic variants (most of them coding) present on the Illumina exome Beadchip to the variability of plasma lipids and stiffness of the common carotid artery. METHODS AND RESULTS: Measurements were obtained from 2283 men and 1398 women, and after filtering and exclusion of monomorphic variants, 32,827 common (minor allele frequency...
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