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Article

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

American journal of human genetics - 1 Nov 2009

Talmud Philippa J, Drenos Fotios, Shah Sonia, Shah Tina, Palmen Jutta, Verzilli Claudio, Gaunt Tom R, Pallas Jacky, Lovering Ruth, Li Kawah, Casas Juan Pablo, Sofat Reecha, Kumari Meena, Rodriguez Santiago, Johnson Toby, Newhouse Stephen J, Dominiczak Anna, Samani Nilesh J, Caulfield Mark, Sever Peter, Stanton Alice, Shields Denis C, Padmanabhan Sandosh, Melander Olle, Hastie Claire, Delles Christian, Ebrahim Shah, Marmot Michael G, Smith George Davey, Lawlor Debbie A, Munroe Patricia B, Day Ian N, Kivimaki Mika, Whittaker John, Humphries Steve E, Hingorani Aroon D

Abstract excerpt

Blood lipids are important cardiovascular disease (CVD) risk factors with both genetic and environmental determinants. The Whitehall II study (n=5592) was genotyped with the gene-centric HumanCVD BeadChip (Illumina). We identified 195 SNPs in 16 genes/regions associated with 3 major lipid fractions and 2 apolipoprotein components at p<10(-5), with the associations being broadly concordant with prior genome-wide...

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Source

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Identifiers

PMID: 19913121
DOI: 10.1016/j.ajhg.2009.10.014
PMCID: PMC2775832

Genes

APOA5
APOE
CETP
LDLR
LPL
ABCA1
APOB
BCL3
BMPR2
CELSR2
GCKR
HMGCR
LIPC
MLXIPL
PCSK9
SMARCA4
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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