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Article

Chromosomal protein HMGN1 modulates the phosphorylation of serine 1 in histone H2A.

Biochemistry - 19 Dec 2006

Postnikov Yuri V, Belova Galina I, Lim Jae-Hwan, Bustin Michael

Abstract excerpt

Here we demonstrate that HMGN1, a nuclear protein that binds specifically to nucleosomes, modulates the level of histone H2A phosphorylation. In Hmgn1-/- cells, loss of HMGN1 elevates the steady-state levels of H2AS1ph throughout the cell cycle. In vitro, HMGN1 reduces the rate of Rsk2- and Msk1-mediated phosphorylation of nucleosomal, but not free, histone H2A. HMGN1 inhibits H2A phosphorylation by binding to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

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Source

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Identifiers

PMID: 17154547
DOI: 10.1021/bi0613271
PMCID: PMC2440507

Genes

HMGN1
HMGN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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