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Article

Allele frequency calibration for SNP based genotyping of DNA pools: A regression based local-global error fusion method.

Computers in biology and medicine - 1 Jun 2015

Rahman Ashfaqur, Hellicar Andrew, Smith Daniel, Henshall John M

Abstract excerpt

BACKGROUND: The costs associated with developing high density microarray technologies are prohibitive for genotyping animals when there is low economic value associated with a single animal (e.g. prawns). DNA pooling is an attempt to address this issue by combining multiple DNA samples prior to genotyping. Instead of genotyping the DNA samples of the individuals, a mixture of DNA samples (i.e. the pool) from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25863000
DOI: 10.1016/j.compbiomed.2015.03.020

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