SNP calling by sequencing pooled samples.

Abstract excerpt

BACKGROUND: Performing high throughput sequencing on samples pooled from different individuals is a strategy to characterize genetic variability at a small fraction of the cost required for individual sequencing. In certain circumstances some variability estimators have even lower variance than those obtained with individual sequencing. SNP calling and estimating the frequency of the minor allele from pooled...

Topics

Join the communities discussing this publication.

• Alleles
• Bayes Theorem
• Gene Frequency
• Genome
• High-Throughput Nucleotide Sequencing