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Article

Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.

Science (New York, N.Y.) - 1 Dec 2006

Pfingsten Jennifer S, Costantino David A, Kieft Jeffrey S

Abstract excerpt

Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a...

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Share to Cryoelectron Microscopy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

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Share to Regulatory Sequences, Ribonucleic Acid

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Source

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Identifiers

PMID: 17124290
DOI: 10.1126/science.1133281
PMCID: PMC2669756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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