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Article

Positioning of subdomain IIId and apical loop of domain II of the hepatitis C IRES on the human 40S ribosome

18 Dec 2008

Abstract excerpt

The 5'-untranslated region of the hepatitis C virus (HCV) RNA contains a highly structured motif called IRES (Internal Ribosome Entry Site) responsible for the cap-independent initiation of the viral RNA translation. At first, the IRES binds to the 40S subunit without any initiation factors so that the initiation AUG codon falls into the P site. Here using an original site-directed cross-linking strategy, we...

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PMID: 19129232
DOI: 10.1093/nar/gkn1026

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Positioning of subdomain IIId and apical loop of domain II of the hepatitis C IRES on the human 40S ribosomePMID 19129232Read ↗

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