Article
HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo.
Development (Cambridge, England) - 15 Jul 2015
Majmundar Amar J, Lee David S M, Skuli Nicolas, Mesquita Rickson C, Kim Meeri N, Yodh Arjun G, Nguyen-McCarty Michelle, Li Bo, Simon M Celeste
Abstract excerpt
Deeper insight into the molecular pathways that orchestrate skeletal myogenesis should enhance our understanding of, and ability to treat, human skeletal muscle disease. It is now widely appreciated that nutrients, such as molecular oxygen (O2), modulate skeletal muscle formation. During early stages of development and regeneration, skeletal muscle progenitors reside in low O2 environments before local blood...
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