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Article

Mechanisms of adaptive angiogenesis to tissue hypoxia.

Angiogenesis - 1 Jan 2008

Fong Guo-Hua

Abstract excerpt

Angiogenesis is mostly an adaptive response to tissue hypoxia, which occurs under a wide variety of situations ranging from embryonic development to tumor growth. In general, angiogenesis is dependent on the accumulation of hypoxia inducible factors (HIFs), which are heterodimeric transcription factors of alpha and beta subunits. Under normoxia, HIF heterodimers are not abundantly present due to oxygen dependent...

Topics

Animals
Blood Vessels
Cell Hypoxia
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Neovascularization, Pathologic
Phenotype
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18327686
DOI: 10.1007/s10456-008-9107-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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