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Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxia

18 Jul 2019

Abstract excerpt

Abstract Extremely reduced oxygen (O2) levels are detrimental to myogenic differentiation and multinucleated myotube formation, and chronic exposure to high-altitude hypoxia has been reported to be an important factor in skeletal muscle atrophy. However, how chronic hypoxia causes muscle dysfunction remains unknown. In the present study, we found that severe hypoxia (1% O2) significantly inhibited the function of...

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PMID: 31320610
DOI: 10.1038/s41419-019-1763-2

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