Article
Hypoxia-induced gene activity in disused oxidative muscle.
Advances in experimental medicine and biology - 1 Jan 2006
Däpp Christoph, Gassmann Max, Hoppeler Hans, Flück Martin
Abstract excerpt
Hypoxia is an important modulator of the skeletal muscle's oxidative phenotype. However, little is known regarding the molecular circuitry underlying the muscular hypoxia response and the interaction of hypoxia with other stimuli of muscle oxidative capacity. We hypothesized that exposure of mice to severe hypoxia would promote the expression of genes involved in capillary morphogenesis and glucose over fatty...
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