Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.

PLoS biology - 1 Oct 2004

Mason Steven D, Howlett Richard A, Kim Matthew J, Olfert I Mark, Hogan Michael C, McNulty Wayne, Hickey Reed P, Wagner Peter D, Kahn C Ronald, Giordano Frank J, Johnson Randall S

Abstract excerpt

The physiological flux of oxygen is extreme in exercising skeletal muscle. Hypoxia is thus a critical parameter in muscle function, influencing production of ATP, utilization of energy-producing substrates, and manufacture of exhaustion-inducing metabolites. Glycolysis is the central source of an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creatine Kinase
Share to Glycogen
Share to Glycolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematocrit

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Lactic Acid

Share to Physical Conditioning, Animal

Share to Physical Exertion

Source

Open in PubMed Open full text

Identifiers

PMID: 15328538
DOI: 10.1371/journal.pbio.0020288
PMCID: PMC514537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15328538-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.PMID 15328538Read ↗

Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle.Semantic proximity Read ↗

Hypoxia-induced gene activity in disused oxidative muscle.Semantic proximity Read ↗

Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice.Semantic proximity Read ↗

Normobaric hypoxia alters the transcriptional response of healthy human skeletal muscles to a single session of high-intensity interval exerciseSemantic proximity Read ↗

HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo.Semantic proximity Read ↗

Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia‐inducible factor 1Semantic proximity Read ↗

Oxygen sensing and metabolic homeostasis.Semantic proximity Read ↗

Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative studySemantic proximity Read ↗

Deletion of the transcriptional coactivator PGC1α in skeletal muscles is associated with reduced expression of genes related to oxidative muscle function.Semantic proximity Read ↗

Repeated-ischaemic exercise enhances mitochondrial and ion transport gene adaptations in human skeletal muscle – Role of muscle redox state and AMPKSemantic proximity Read ↗

AMPK: a key sensor of fuel and energy status in skeletal muscle.Semantic proximity Read ↗

Effect of hypoxia exposure on the recovery of skeletal muscle phenotype during regeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.