Article
Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner.
PloS one - 1 Jan 2012
Wagegg Markus, Gaber Timo, Lohanatha Ferenz L, Hahne Martin, Strehl Cindy, Fangradt Monique, Tran Cam Loan, Schönbeck Kerstin, Hoff Paula, Ode Andrea, Perka Carsten, Duda Georg N, Buttgereit Frank
Abstract excerpt
BACKGROUND: Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and differentiation of multipotent human mesenchymal stromal cells (hMSC). Therefore, we analyzed the impact of hypoxia and HIF-1 on the competitive differentiation potential of hMSCs towards adipogenic and osteogenic lineages....
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