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Article

Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene

16 Dec 2023

Abstract excerpt

Abstract Background Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlying the effects of hypoxia on human myoblast differentiation remain unclear. The hypoxic response pathway is of particular interest in patients with hereditary muscular dystrophies since many present respiratory impairment and muscle regeneration defects. For example, an...

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PMID: 38104132
DOI: 10.1186/s13395-023-00330-2

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Related research

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Research trail→

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Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal genePMID 38104132Read ↗

A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4.Semantic proximity Read ↗

Gene expression during normal and FSHD myogenesisSemantic proximity Read ↗

Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.Semantic proximity Read ↗

DUX4 Differentially Regulates Transcriptomes of Human Rhabdomyosarcoma and Mouse C2C12 CellsSemantic proximity Read ↗

Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing miceSemantic proximity Read ↗

The FSHD atrophic myotube phenotype is caused by DUX4 expression.Semantic proximity Read ↗

Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activitySemantic proximity Read ↗

DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast ProliferationSemantic proximity Read ↗

Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophySemantic proximity Read ↗

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies.Semantic proximity Read ↗

Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei.Semantic proximity Read ↗

Relationship of <i>DUX4</i> and target gene expression in FSHD myocytesSemantic proximity Read ↗

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