Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.

doi:10.1186/s13059-017-1156-8

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Article

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.

Genome biology - 26 Jan 2017

Ecker Simone, Chen Lu, Pancaldi Vera, Bagger Frederik O, Fernández José María, Carrillo de Santa Pau Enrique, Juan David, Mann Alice L, Watt Stephen, Casale Francesco Paolo, Sidiropoulos Nikos, Rapin Nicolas, Merkel Angelika, Stunnenberg Hendrik G, Stegle Oliver, Frontini Mattia, Downes Kate, Pastinen Tomi, Kuijpers Taco W, Rico Daniel, Valencia Alfonso, Beck Stephan, Soranzo Nicole, Paul Dirk S

Abstract excerpt

BACKGROUND: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. RESULTS: We apply a novel analytical approach to measure and compare transcriptional and epigenetic variability genome-wide across CD14+CD16- monocytes, CD66b+CD16+ neutrophils, and CD4+CD45RA+ naïve T cells from the...

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Identifiers

PMID: 28126036
DOI: 10.1186/s13059-017-1156-8
PMCID: PMC5270224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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