Article
Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway.
Gene - 15 Oct 2015
van der Sluis Rencia, Badenhorst Christoffel P S, Erasmus Elardus, van Dyk Etresia, van der Westhuizen Francois H, van Dijk Alberdina A
Abstract excerpt
Thorough investigation of the glycine conjugation pathway has been neglected. No defect of the glycine conjugation pathway has been reported and this could reflect the essential role of glycine conjugation in hepatic metabolism. Therefore, we hypothesised that genetic variation in the open reading frame (ORF) of the GLYAT gene should be low and that deleterious alleles would be found at low frequencies. This...
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