Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl-CoA.

doi:10.3390/ijms22063129

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Article

Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl-CoA.

International journal of molecular sciences - 18 Mar 2021

Rohwer Johann M, Schutte Chantelle, van der Sluis Rencia

Abstract excerpt

The glycine conjugation pathway in humans is involved in the metabolism of natural substrates and the detoxification of xenobiotics. The interactions between the various substrates in this pathway and their competition for the pathway enzymes are currently unknown. The pathway consists of a mitochondrial xenobiotic/medium-chain fatty acid: coenzyme A (CoA) ligase (ACSM2B) and glycine N-acyltransferase (GLYAT)....

Topics

Acyl Coenzyme A
Acyltransferases
Animals
Conserved Sequence
Gene Frequency
Glycine
Humans
Kinetics
Mutation
Phylogeny

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PMID: 33803916
DOI: 10.3390/ijms22063129
PMCID: PMC8003330

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