Article
The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.
The Journal of biological chemistry - 5 Sept 2003
O'Byrne James, Hunt Mary C, Rai Dilip K, Saeki Masayumi, Alexson Stefan E H
Abstract excerpt
Bile acid-CoA:amino acid N-acyltransferase (BACAT) catalyzes the conjugation of bile acids to glycine and taurine for excretion into bile. By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in human BACAT (hBACAT) and identifying BACAT as a member of the type I acyl-CoA thioesterase gene family. We therefore hypothesized...
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