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Article

Structural Rigidity and Protein Thermostability in Variants of Lipase A from Bacillus subtilis.

PloS one - 1 Jan 2015

Rathi Prakash Chandra, Jaeger Karl-Erich, Gohlke Holger

Abstract excerpt

Understanding the origin of thermostability is of fundamental importance in protein biochemistry. Opposing views on increased or decreased structural rigidity of the folded state have been put forward in this context. They have been related to differences in the temporal resolution of experiments and computations that probe atomic mobility. Here, we find a significant (p = 0.004) and fair (R2 = 0.46) correlation...

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Identifiers

PMID: 26147762
DOI: 10.1371/journal.pone.0130289
PMCID: PMC4493141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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