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Article

Thermostabilizing mutations preferentially occur at structural weak spots with a high mutation ratio.

Journal of biotechnology - 15 Jun 2012

Rathi Prakash C, Radestock Sebastian, Gohlke Holger

Abstract excerpt

We apply Constraint Network Analysis (CNA) to investigate the relationship between structural rigidity and thermostability of five citrate synthase (CS) structures over a temperature range from 37 °C to 100 °C. For the first time, we introduce an ensemble-based variant of CNA and model the temperature-dependence of hydrophobic interactions in the constraint network. A very good correlation between the predicted...

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PMID: 22326626
DOI: 10.1016/j.jbiotec.2012.01.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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