Learning the changes of barnase mutants thermostability from structural fluctuations obtained using anisotropic network modeling.

Abstract excerpt

In biotechnology applications, rational design of new proteins with improved physico-chemical properties includes a number of important tasks. One of the greatest practical and fundamental challenges is the design of highly thermostable protein enzymes that maintain catalytic activity at high temperatures. This problem may be solved by introducing mutations into the wild-type enzyme protein. In this work, to...

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