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Article

Automated optimization of the solubility of a hyper-stable α-amylase.

Open biology - 1 May 2024

Ali Montader, Greenig Matthew, Oeller Marc, Atkinson Misha, Xu Xing, Sormanni Pietro

Abstract excerpt

Most successes in computational protein engineering to date have focused on enhancing one biophysical trait, while multi-trait optimization remains a challenge. Different biophysical properties are often conflicting, as mutations that improve one tend to worsen the others. In this study, we explored the potential of an automated computational design strategy, called CamSol Combination, to optimize solubility and...

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Identifiers

PMID: 38745462
DOI: 10.1098/rsob.240014
PMCID: PMC11293438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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