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Article

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands.

Molecular cell - 16 Jul 2015

Johnson Robert E, Klassen Roland, Prakash Louise, Prakash Satya

Abstract excerpt

Genetic studies with S. cerevisiae Polδ (pol3-L612M) and Polε (pol2-M644G) mutant alleles, each of which display a higher rate for the generation of a specific mismatch, have led to the conclusion that Polε is the primary leading strand replicase and that Polδ is restricted to replicating the lagging strand template. Contrary to this widely accepted view, here we show that Polδ plays a major role in the...

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Identifiers

PMID: 26145172
DOI: 10.1016/j.molcel.2015.05.038
PMCID: PMC4517859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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