Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Division of labor at the eukaryotic replication fork.

Molecular cell - 25 Apr 2008

Nick McElhinny Stephanie A, Gordenin Dmitry A, Stith Carrie M, Burgers Peter M J, Kunkel Thomas A

Abstract excerpt

DNA polymerase delta (Pol delta) and DNA polymerase epsilon (Pol epsilon) are both required for efficient replication of the nuclear genome, yet the division of labor between these enzymes has remained unclear for many years. Here we investigate the contribution of Pol delta to replication of the leading and lagging strand templates in Saccharomyces cerevisiae using a mutant Pol delta allele (pol3-L612M) whose...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Reporter
Share to DNA Mismatch Repair
Share to DNA Polymerase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase III

Share to DNA Replication

Share to MutS Homolog 2 Protein

Share to Replication Origin

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18439893
DOI: 10.1016/j.molcel.2008.02.022
PMCID: PMC2654179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Division of labor at the eukaryotic replication fork.PMID 18439893Read ↗

Yeast DNA polymerase epsilon participates in leading-strand DNA replication.Semantic proximity Read ↗

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands.Semantic proximity Read ↗

Mismatch Repair Balances Leading and Lagging Strand DNA Replication FidelitySemantic proximity Read ↗

Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand.Semantic proximity Read ↗

The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains.Semantic proximity Read ↗

Polymerase dynamics at the eukaryotic DNA replication fork.Semantic proximity Read ↗

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repairSemantic proximity Read ↗

Genome-wide model for the normal eukaryotic DNA replication fork.Semantic proximity Read ↗

Unique error signature of the four-subunit yeast DNA polymerase epsilon.Semantic proximity Read ↗

Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication fork.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.