Article
Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia.
Stem cell research - 1 Nov 2016
Nimsanor Natakarn, Jørring Ida, Rasmussen Mikkel A, Clausen Christian, Mau-Holzmann Ulrike A, Kitiyanant Narisorn, Nielsen Jørgen E, Nielsen Troels T, Hyttel Poul, Holst Bjørn, Schmid Benjamin
Abstract excerpt
Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the gene coding the microtubule-associated protein tau (MAPT) can cause FTDP-17 but the underlying mechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.