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Article

Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability.

European journal of drug metabolism and pharmacokinetics - 1 Oct 2016

Mourão Artemísia L, de Abreu Fabiana G, Fiegenbaum Marilu

Abstract excerpt

BACKGROUND AND OBJECTIVES: Propofol is the most commonly used hypnotic worldwide, but its effective dose varies greatly between individuals. The present study sought to investigate the relationship between the c.516G>T polymorphism in the CYP2B6 (cytochrome P450 2B6) gene and the required propofol dose. METHODS: One hundred and eight patients treated with propofol were recruited, and environmental, clinical and...

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PMID: 26141406
DOI: 10.1007/s13318-015-0289-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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