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Article

Pharmacogenetics, plasma concentrations, clinical signs and EEG during propofol treatment.

Basic & clinical pharmacology & toxicology - 1 Dec 2014

Khan Muhammad Suleman, Zetterlund Eva-Lena, Gréen Henrik, Oscarsson Anna, Zackrisson Anna-Lena, Svanborg Eva, Lindholm Maj-Lis, Persson Harald, Eintrei Christina

Abstract excerpt

A variety of techniques have been developed to monitor the depth of anaesthesia. Propofol's pharmacokinetics and response vary greatly, which might be explained by genetic polymorphisms. We investigated the impact of genetic variations on dosage, anaesthetic depth and recovery after total intravenous anaesthesia with propofol. A total of 101 patients were enrolled in the study. The plasma concentration of...

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Share to Cytochrome P-450 CYP2B6
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroencephalography

Share to Glucuronosyltransferase

Share to Polymorphism, Genetic

Share to Propofol

Share to Receptors, GABA-A

Share to UDP-Glucuronosyltransferase 1A9

Source

Identifiers

PMID: 24891132
DOI: 10.1111/bcpt.12277

Genes

GABRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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