Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia.

European journal of clinical pharmacology - 1 Apr 2012

Loryan Irena, Lindqvist Marja, Johansson Inger, Hiratsuka Masahiro, van der Heiden Ilse, van Schaik Ron H N, Jakobsson Jan, Ingelman-Sundberg Magnus

Abstract excerpt

PURPOSE: The basis of high intersubject variability of propofol metabolism is unclear. Therefore, we examined the influence of genetic polymorphisms of the key metabolizing enzymes cytochrome P450 2B6 (CYP2B6) and uridine diphosphate (UDP)-glucuronosyltransferase 1A9 (UGT1A9), age, and sex on propofol biotransformation in vitro and in vivo. METHODS: Plasma concentrations of propofol, 4-hydroxypropofol, and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

Share to Oxidoreductases, N-Demethylating

Share to Propofol

Share to Sex Factors

Share to UDP-Glucuronosyltransferase 1A9

Source

Identifiers

PMID: 22006347
DOI: 10.1007/s00228-011-1132-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia.PMID 22006347Read ↗

Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics.Semantic proximity Read ↗

Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9).Semantic proximity Read ↗

Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and PharmacodynamicsSemantic proximity Read ↗

Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability.Semantic proximity Read ↗

In Vivo Glucuronidation Activity of Drugs in Neonates: Extensive Interindividual Variability Despite Their Young AgeSemantic proximity Read ↗

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.Semantic proximity Read ↗

The effect of UGT1A9, CYP2B6 and CYP2C9 genes polymorphism on individual differences in propofol pharmacokinetics among Polish patients undergoing general anaesthesia.Semantic proximity Read ↗

Association of the CYP2B6 c.516G>T polymorphism with high blood propofol concentrations in women from northern Greece.Semantic proximity Read ↗

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model systemSemantic proximity Read ↗

An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia.Semantic proximity Read ↗

Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia.Semantic proximity Read ↗

The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.