Article
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia.
Current drug metabolism - 1 Jan 2023
Alrabayah Mustafa, Massad Islam Mohammad, Imraish Amer, Jarrar Yazun, Massad Faysal, Guzu Hasan, Abufares Basil, Al-Oran Afnan, Alkharabsheh Malik Mohammad, Haroon Nour, Ismail Mohammad Asa'ad, Qaqish Bara'a, Zihlif Malik
Abstract excerpt
BACKGROUND: Propofol is the most commonly used general anesthetic drug in many countries, including Jordan. However, there is a wide variation in the propofols' dose and response among the patients. Genetic variation in the cytochrome (CYP) 2B6 gene affects propofol metabolism and might affect propofol dose and response. AIMS: This study aimed to determine the influence of major genetic alleles of the CYP2B6...
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