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Article

The effect of UGT1A9, CYP2B6 and CYP2C9 genes polymorphism on individual differences in propofol pharmacokinetics among Polish patients undergoing general anaesthesia.

Journal of applied genetics - 1 May 2017

Mikstacki Adam, Zakerska-Banaszak Oliwia, Skrzypczak-Zielinska Marzena, Tamowicz Barbara, Prendecki Michał, Dorszewska Jolanta, Molinska-Glura Marta, Waszak Malgorzata, Slomski Ryszard

Abstract excerpt

Propofol (2,6-diisopropylphenol) is one of the safest and most commonly used anaesthetic agents for intravenous general anaesthesia. However, in clinical practice, a large inter-individual variability in response to propofol is observed. To limit the risk of adverse effects, pharmacogenetic investigations are recommended. The aim of our study was to verify the impact of genetic changes c.516G>T in the CYP2B6,...

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Identifiers

PMID: 27826892
DOI: 10.1007/s13353-016-0373-2
PMCID: PMC5391385

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