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Article

Effect of CYB2B6 (c.516G>T), CYP2C9 (c.1075A>C) and UGT1A9 (c.98T>C) polymorphisms on propofol pharmacokinetics in patients submitted to colonoscopy: a cohort study.

Postgraduate medical journal - 22 May 2023

Poma Mara Aparecida Maricato, Ribeiro Junior Howard Lopes, Costa Eugênio Araújo, Paier Carlos Roberto Koscky, Brasil Laís Lacerda, Lima Luína Benevides, Nobre Livia Maria Soares, Leite Tayales Tavares, Lima-Júnior Roberto César Pereira, Quidute Ana Rosa Pinto, de Moraes Maria Elisabete Amaral, de Moraes Filho Manoel Odorico

Abstract excerpt

BACKGROUND: The aim of this study was to investigate the effect of CYB2B6 (c.516G>T, rs3745274), CYP2C9 (c.1075A>C, rs1057910) and UGT1A9 (c.98T>C, rs72551330) polymorphisms on the pharmacokinetics of single-drug propofol in adult patients undergoing intravenous sedation. METHODS: In this prospective clinical study, a total of 124 patients undergoing anaesthesia with propofol, as a single drug, were evaluated...

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Share to Cohort Studies
Share to Cytochrome P-450 CYP2B6
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Share to Electroencephalography
Share to Polymorphism, Single Nucleotide
Share to Propofol
Share to UDP-Glucuronosyltransferase 1A9

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Identifiers

PMID: 37227973
DOI: 10.1136/postgradmedj-2021-141375

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